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December 23, 2021
Brief Report

Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma

Abstract Full Text
has audio
JAMA Oncol. Published online December 23, 2021. doi:10.1001/jamaoncol.2021.5981

This phase 3 randomized clinical trial reports the final overall survival, safety, and exploratory analyses of the association of transcriptomic subsets with overall survival from IMmotion151.

Review

Human Leukocyte Antigen Class I Antigen-Processing Machinery Upregulation by Anticancer Therapies in the Era of Checkpoint Inhibitors: A Review

Abstract Full Text
JAMA Oncol. Published online December 23, 2021. doi:10.1001/jamaoncol.2021.5970

This narrative review provides an overview of chemotherapy and targeted therapies effective at enhancing human leukocyte antigen class I antigen-processing machinery component expression and function in cancer cells and their treatment synergy with immune checkpoint inhibitors.

Comment & Response

Metformin—A Thought-Provoking Addition to Anticancer Therapies

Abstract Full Text
JAMA Oncol. Published online December 23, 2021. doi:10.1001/jamaoncol.2021.6726

Metformin—A Thought-Provoking Addition to Anticancer Therapies—Reply

Abstract Full Text
JAMA Oncol. Published online December 23, 2021. doi:10.1001/jamaoncol.2021.6729
December 16, 2021
Original Investigation

Apatinib vs Placebo in Patients With Locally Advanced or Metastatic, Radioactive Iodine–Refractory Differentiated Thyroid Cancer: The REALITY Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online December 16, 2021. doi:10.1001/jamaoncol.2021.6268

This randomized clinical trial evaluated the use of apatinib vs placebo in patients with locally advanced or metastatic radioactive iodine–refractory differentiated thyroid cancer.

Association of Antiparietal Cell and Anti-Intrinsic Factor Antibodies With Risk of Gastric Cancer

Abstract Full Text
open access
JAMA Oncol. Published online December 16, 2021. doi:10.1001/jamaoncol.2021.5395

This cohort study seeks to determine the association of prediagnostic autoantibodies to gastric mucosa with gastric cancer risk.

Viewpoint

The Urgent Need for Affordability Curricula at US Medical Schools: The Cost of Avoiding Cost for the Next Generation of Physicians

Abstract Full Text
JAMA Oncol. Published online December 16, 2021. doi:10.1001/jamaoncol.2021.6113

This Viewpoint urges medical schools to teach cost education so that new physicians can offer patients and families the best treatment they can afford.

Invited Commentary

Treatment for Advanced and Metastatic Thyroid Cancer Refractory to Standard Treatment—We Need to Know the When, What, and Who

Abstract Full Text
JAMA Oncol. Published online December 16, 2021. doi:10.1001/jamaoncol.2021.6247
December 9, 2021
Original Investigation

Diversity Trends by Sex and Underrepresented in Medicine Status Among US Radiation and Medical Oncology Faculty Over 5 Decades

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.6011

This cross-sectional study uses data from the Association of American Medical Colleges to report trends in academic faculty representation by sex and by race and ethnicity for radiation oncology and medical oncology departments.

Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.5948

This randomized clinical trial examines the efficacy of armodafinil in reducing fatigue in patients with high-grade glioma and moderate-to-severe fatigue.

Review

Radiofrequency Radiation and Cancer: A Review

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.5964

This review considers radiofrequency radiation and potential biophysical mechanisms of cancer induction and discusses the existent epidemiological evidence in humans and laboratory animals.

Viewpoint

Reconceptualizing Risk-Benefit Assessment of Novel Cancer Therapies to Expand Global Access and Reduce Worldwide Mortality

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.5945

This article discusses the availability of novel cancer therapies and health care infrastructure in high-income vs low- and middle-income countries.

Invited Commentary

Solving the Equation of Structural Inequities in the Oncology Workforce

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.6010
Comment & Response

Carboplatin During Craniospinal Radiotherapy for Children With Group 3 Medulloblastoma—A New Standard of Care?

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.6523

Carboplatin During Craniospinal Radiotherapy for Children With Group 3 Medulloblastoma—A New Standard of Care?—Reply

Abstract Full Text
JAMA Oncol. Published online December 9, 2021. doi:10.1001/jamaoncol.2021.6526
December 2, 2021
Original Investigation

Patterns of Adjuvant Chemotherapy Use and Association With Survival in Adults 80 Years and Older With Pancreatic Adenocarcinoma

Abstract Full Text
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.5407

This cohort study describes patterns of adjuvant chemotherapy use in patients 80 years and older following surgical resection of pancreatic ductal adenocarcinoma and to compare overall survival of patients who received AC vs those who did not.

Immune-Mediated Diseases Associated With Cancer Risks

Abstract Full Text
open access
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.5680

This cohort study uses data from the UK Biobank to assess the associations of immune-mediated diseases with risk of total and individual cancers and of organ-specific immune-mediated diseases with risk of local and extralocal cancers.

Brief Report

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer: A US Nationwide Veterans Affairs Study

Abstract Full Text
open access has active quiz
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.5771

This cohort study assesses the association between SARS-CoV-2 vaccination and SARS-CoV-2 infections among a population of Veterans Affairs (VA) patients with cancer.

Viewpoint

Neutralizing Antibody Testing in Patients With Multiple Myeloma Following COVID-19 Vaccination

Abstract Full Text
free access
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.5942

This Viewpoint discusses the benefits of titer testing for anti–SARS-CoV-2 antibodies in patients with severe immunosuppression, including patients with multiple myeloma, following COVID-19 vaccination.

Invited Commentary

Insights Into Immune-Mediated Disease and Cancer Risk—Delivering on the Promise of UK Biobank Big Data

Abstract Full Text
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.5572
Cancer Care Chronicles

Pink Ribbons

Abstract Full Text
JAMA Oncol. Published online December 2, 2021. doi:10.1001/jamaoncol.2021.6413

In this essay, a physician describes her experience learning and accepting that she is BRCA2 positive.

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